Positron Emission Tomography (PET) is a non-invasive imaging procedure used to assess metabolic activity and perfusion in various organ systems in the human body. Images are obtained from positron-emitting radioisotopes that are usually administered intravenously. 2-[F18] fluoro-2-deoxy-D-glucose (FDG) is most often used as the radioisotope tracer in PET imaging procedures for cardiac (i.e., myocardial viability), neuropsychiatric and oncologic evaluations. In addition, myocardial perfusion imaging of the heart utilizes N-13 and Rb-82 tracers. Therefore, designation of these different tracers will be identified within each of the four separate sets of medical necessity criteria.
PET scanning differs from its anatomic-based imaging counterparts (e.g., Computed Tomography (CT)) by generating functional images of pathophysiologic activity. Please note that CT scanners are now being combined with PET scanners. This dual technology poses several advantages such as shorter imaging times and the automatic co registration of CT (anatomic) and PET (metabolic) information.
Per Pub. 100-03, Chapter 1, Part 4, Section 220.6, numerous clinical indications have been approved for imaging via a National Coverage Determination (NCD). CMS revised NCD 220.6 effective October 30, 2009, for services performed on or after Apri1 3, 2009, on patients with known or suspected cancer. The revised national coverage provides four categories of coverage for two categories of cancer management. The coverage categories are: covered (without exception), covered with exception, covered with evidence development, and non-covered. The two categories of cancer management are: Initial Treatment Strategy and Subsequent Treatment Strategy.
Per Pub. 100-03, Chapter 1, Part 4, Section 220.6.19 (Change Request 6861), effective July 6, 2010, for services performed on or after February 26, 2010, PET imaging performed with NaF-18 to inform initial or subsequent treatment strategy is covered for known or suspected metastatic cancer to bone for patients enrolled in (and providers participating in) a prospective clinical study as outlined in Pub. 100-03, Section 220.6.
This LCD contains several sets of covered ICD-9-CM diagnosis codes for use in automated claim review. The first sets apply to all PET imaging services performed prior to April 3, 2009. The subsequent sets apply to PET imaging services performed on or after April 3, 2009, on patients with known or suspected cancer and PET imaging services with NaF performed on or after February 26, 2010.
Because of the complexity of the NCD’s coverage and required coding, providers of PET imaging services must review the NCD and code their claims appropriately and accordingly.
Please note that some non-covered indications of PET may be in areas of nuclear medicine testing where dedicated PET CPT codes have not traditionally been used (e.g., bone scans). In such instances, G0235, as described in the Related Article Coding Guidelines, must be used.
Limitations:
Notice: This LCD imposes diagnosis limitations that support diagnosis to procedure code automated denials. However, services performed for any given diagnosis must meet all of the indications and limitations stated in this policy, the general requirements for medical necessity as stated in CMS payment policy manuals, any and all existing CMS national coverage determinations, and all Medicare payment rules.
As published in CMS IOM 100-08, Section 13.5.1, to be covered under Medicare, a service shall be reasonable and necessary. When appropriate, contractors shall describe the circumstances under which the proposed LCD for the service is considered reasonable and necessary under Section 1862(a)(1)(A). Contractors shall consider a service to be reasonable and necessary if the contractor determines that the service is:
  • Safe and effective.
  • Not experimental or investigational (exception: routine costs of qualifying clinical trial services with dates of service on or after September 19, 2000, which meet the requirements of the clinical trials NCD are considered reasonable and necessary).
  • Appropriate, including the duration and frequency that is considered appropriate for the service, in terms of whether it is:
    • Furnished in accordance with accepted standards of medical practice for the diagnosis or treatment of the patient’s condition or to improve the function of a malformed body member.
    • Furnished in a setting appropriate to the patient’s medical needs and condition.
    • Ordered and furnished by qualified personnel.
    • One that meets, but does not exceed, the patient’s medical need.
    • At least as beneficial as an existing and available medically appropriate alternative.
Bill Type Codes
Contractors may specify Bill Types to help providers identify those Bill Types typically used to report this service. Absence of a Bill Type does not guarantee that the policy does not apply to that Bill Type. Complete absence of all Bill Types indicates that coverage is not influenced by Bill Type and the policy should be assumed to apply equally to all claims.
12X, 13X, 18X, 21X, 22X, 23X, 83X, 85X
Revenue Codes
Contractors may specify Revenue Codes to help providers identify those Revenue Codes typically used to report this service. In most instances Revenue Codes are purely advisory; unless specified in the policy services reported under other Revenue Codes are equally subject to this coverage determination. Complete absence of all Revenue Codes indicates that coverage is not influenced by Revenue Code and the policy should be assumed to apply equally to all Revenue Codes.
Note: TrailBlazer has identified the Bill Type and Revenue Codes applicable for use with the CPT/HCPCS codes included in this LCD. Providers are reminded that not all CPT/HCPCS codes listed can be billed with all Bill Type and/or Revenue Codes listed. CPT/HCPCS codes are required to be billed with specific Bill Type and Revenue Codes. Providers are encouraged to refer to the CMS Internet-Only Manual Publication 100-04, Claims Processing Manual, for further guidance.
0404
CPT/HCPCS Codes
Note:
Providers are reminded to refer to the long descriptors of the CPT codes in their CPT book. The American Medical Association (AMA) and CMS require the use of short CPT descriptors in policies published on the Web.
78459©
Heart muscle imaging (pet)
78491©
Heart image (pet), single
78492©
Heart image (pet), multiple
78608©
Brain imaging (pet)
78811©
Tumor imaging (pet), limited
78812©
Tumor image (pet)/skull-thigh
78813©
Tumor image (pet) full body
78814©
Tumor image pet/ct, limited
78815©
Tumor image pet/ct skull-thigh
78816©
Tumor image pet/ct full body
A9526*
Nitrogen N-13 ammonia
A9552*
F18 fdg
A9555*
Rb82 rubidium
A9580*
NaF-18
*Note: HCPCS codes of the radiopharmaceutical tracer must be billed on the same claim as the PET imaging CPT code.
ICD-9-CM Codes That Support Medical Necessity
The CPT/HCPCS codes included in this LCD will be subjected to “procedure to diagnosis” editing. The following lists include only those diagnoses for which the identified CPT/HCPCS procedures are covered. If a covered diagnosis is not on the claim, the edit will automatically deny the service as not medically necessary.
For PET imaging services for non-cancer-related conditions
Medicare is establishing the following limited coverage for CPT/HCPCS codes A9552 and 78459:
Covered for:
402.00–402.01
Malignant hypertensive heart disease without/with heart failure
410.00–410.02 begin_of_the_skype_highlighting            00–410.02      end_of_the_skype_highlighting
Acute myocardial infarction of anterolateral wall
410.10–410.12
Acute myocardial infarction of other anterior wall
410.20–410.22
Acute myocardial infarction of inferolateral wall
410.30–410.32
Acute myocardial infarction of inferoposterior wall
410.40–410.42
Acute myocardial infarction of other inferior wall
410.50–410.52
Acute myocardial infarction of other lateral wall
410.60–410.62
True posterior wall infarction
410.70–410.72
Subendocardial infarction
410.80–410.82
Acute myocardial infarction of other specified sites
410.90–410.92
Acute myocardial infarction, unspecified site
411.0–411.1
Other acute and subacute forms of ischemic heart disease
411.81
Acute coronary occlusion without myocardial infarction
411.89
Other acute and subacute forms of Ischemic heart disease other
412
Old myocardial infarction
413.0–413.1
Angina pectoris
413.9
Other and unspecified angina pectoris
414.00–414.03 begin_of_the_skype_highlighting            00–414.03      end_of_the_skype_highlighting
Coronary atherosclerosis
414.10
Aneurysm of heart (wall)
414.3
Coronary atherosclerosis due to lipid rich plaque
414.8
Other specified forms of chronic ischemic heart disease
425.0–425.5
Cardiomyopathy
425.7–425.9
Cardiomyopathy
428.0–428.1
Heart failure
428.20–428.23
Systolic heart failure
428.30–428.33
Diastolic heart failure
428.40–428.43
Combined systolic and diastolic heart failure
428.9
Heart failure, unspecified
793.91
Image test inconclusive due to excess body fat
793.99
Other nonspecific (abnormal) findings on radiological and other examination of body structure
V70.7*
Examination of participant in clinical trial
Note: V70.7* is used on claims for participants registered in CMS-approved clinical trial. Part A only
Medicare is establishing the following limited coverage for CPT/HCPCS codes A9526, A9555, 78491 and 78492:
Covered for:
410.00–410.02 begin_of_the_skype_highlighting            00–410.02      end_of_the_skype_highlighting
Acute myocardial infarction of anterolateral wall
410.10–410.12
Acute myocardial infarction of other anterior wall
410.20–410.22
Acute myocardial infarction of inferolateral wall
410.30–410.32
Acute myocardial infarction of inferoposterior wall
410.40–410.42
Acute myocardial infarction of other inferior wall
410.50–410.52
Acute myocardial infarction of other lateral wall
410.60–410.62
True posterior wall infarction
410.70–410.72
Subendocardial infarction
410.80–410.82
Acute myocardial infarction of other specified sites
410.90–410.92
Acute myocardial infarction, unspecified site
411.0–411.1
Other acute and subacute forms of ischemic heart disease
411.81
Acute coronary occlusion without myocardial infarction
411.89
Other acute and subacute forms of ischemic heart disease
412
Old myocardial infarction
413.0–413.1
Angina pectoris
413.9
Other and unspecified angina pectoris
414.00–414.07 begin_of_the_skype_highlighting            00–414.07      end_of_the_skype_highlighting
Coronary atherosclerosis
414.10–414.12
Aneurysm and dissection of heart
414.19
Other aneurysm of heart
414.3
Coronary atherosclerosis due to lipid rich plaque
414.8–414.9
Other forms of chronic ischemic heart disease
427.0–427.2
Cardiac dysrhythmias
427.41–427.42
Ventricular fibrillation and flutter
427.5
Cardiac Arrest
428.0–428.1
Heart failure
428.20–428.23
Systolic heart failure
428.30–428.33
Diastolic heart failure
428.40–428.43
Combined systolic and diastolic heart failure
429.4–429.6
Ill-defined descriptions and complications of heart disease
429.81–429.83
Other ill-defined heart diseases
429.89
Other ill-defined heart diseases
786.02
Symptoms involving respiratory system and other chest symptoms, orthopnea
786.05
Shortness of breath
786.09
Other dyspnea & respiratory abnormalities (respiratory distress)
786.50–786.51
Chest pain
786.59
Other chest pain
793.91
Image test inconclusive due to excess body fat
793.99
Other nonspecific (abnormal) findings on radiological and other examination of body structure
794.31
Abnormal electrocardiogram
996.72
Other complications due to other cardiac device implant and graft
996.83
Complications of transplanted heart
V42.1
Heart replaced by transplant
V45.81–V45.82
Other post-procedural status
V58.11
Encounter for antineoplastic chemotherapy
V72.81*
Pre-operative cardiovascular examination
Note: See the “Indications and Limitations of Coverage and/or Medical Necessity” section in this policy as well as “Coding Guidelines” in the related article regarding appropriate billing for preoperative studies.
Medicare is establishing the following limited coverage for CPT/HCPCS codes A9552 and 78608 for differential diagnosis of Alzheimer’s versus frontotemporal dementia:
Covered for:
290.0
Senile dementia, uncomplicated
290.10–290.13
Presenile dementia
290.20–290.21
Senile dementia with delusional or depressive features
290.3
Senile dementia with delirium
331.0
Other cerebral degenerations, Alzheimer’s disease
331.11
Other cerebral degenerations, frontotemporal dementia, Pick’s disease
331.19
Other cerebral degenerations, other frontotemporal dementia
331.2
Other cerebral degenerations, senile degeneration of brain
331.9
Cerebral degeneration, unspecified
345.01
Generalized nonconvulsive epilepsy, with intractable epilepsy
345.11
Generalized convulsive epilepsy, with intractable epilepsy
345.2–345.3
Epilepsy and recurrent seizures
345.41
Partial epilepsy, with impairment of consciousness, with intractable epilepsy
345.51
Partial epilepsy, without mention of impairment of consciousness, with intractable epilepsy
345.61
Infantile spasms, with intractable epilepsy
345.71
Epilepsia partialis continua, with intractable epilepsy
345.81
Other forms of epilepsy, with intractable epilepsy
345.91
Epilepsy, unspecified, with intractable epilepsy
780.39
General symptoms, other convulsions
780.93
General symptoms, memory loss
V70.7*
Examination of participant in clinical trial
Note: V70.7* is used on claims for participants registered in CMS-approved clinical trial. Part A only
For PET imaging services performed prior to April 3, 2009, on patients with known or suspected cancer
Medicare is establishing the following limited coverage for CPT/HCPCS codes A9552, 78811, 78812, 78813, 78814, 78815 and 78816:
Covered for:
140.0–140.1
Malignant neoplasm of lip
140.3–140.6
Malignant neoplasm of lip
140.8–140.9
Malignant neoplasm of lip
141.0–141.6
Malignant neoplasm of tongue
141.8–141.9
Malignant neoplasm of tongue
142.0–142.2
Malignant neoplasm of major salivary glands
142.8–142.9
Malignant neoplasm of major salivary glands
143.0–143.1
Malignant neoplasm of gum
143.8–143.9
Malignant neoplasm of gum
144.0–144.1
Malignant neoplasm of floor of mouth
144.8–144.9
Malignant neoplasm of floor of mouth
145.0–145.6
Malignant neoplasm of other and unspecified parts of mouth
145.8–145.9
Malignant neoplasm of other and unspecified parts of mouth
146.0–146.9
Malignant neoplasm of oropharynx
147.0–147.3
Malignant neoplasm of nasopharynx
147.8–147.9
Malignant neoplasm of nasopharynx
148.0–148.3
Malignant neoplasm of hypopharynx
148.8–148.9
Malignant neoplasm of hypopharynx
149.0–149.1
Malignant neoplasm of other and ill-defined sites within the lip, oral cavity, and pharynx
149.8–149.9
Malignant neoplasm of other and ill-defined sites within the lip, oral cavity, and pharynx
150.0–150.5
Malignant neoplasm of esophagus
150.8–150.9
Malignant neoplasm of esophagus
153.0–153.9
Malignant neoplasm of colon
154.0–154.3
Malignant neoplasm of rectum, rectosigmoid junction and anus
154.8
Other malignant neoplasm of rectum, rectosigmoid junction and anus
160.0–160.5
Malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
160.8–160.9
Malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
161.0–161.3
Malignant neoplasm of larynx
161.8–161.9
Malignant neoplasm of larynx
162.0
Malignant neoplasm of trachea
162.2–162.5
Malignant neoplasm of trachea, bronchus and lung
162.8–162.9
Malignant neoplasm of trachea, bronchus and lung
170.0–170.1
Malignant neoplasm of bone and articular cartilage
171.0
Malignant neoplasm of connective and other soft tissue of head, face, and neck
172.0–172.9
Malignant melanoma of skin
174.0–174.6
Malignant neoplasm of female breast
174.8–174.9
Malignant neoplasm of female breast
175.0
Malignant neoplasm of male breast, nipple and areola
175.9
Malignant neoplasm of other and unspecified sites of male breast
180.0–180.1
Malignant neoplasm of cervix uteri
180.8–180.9
Malignant neoplasm of cervix uteri
184.0–184.4
Malignant neoplasm of other and unspecified sites of female genital organs
184.8–184.9
Malignant neoplasm of other specified/unspecified sites of female genital organs
187.1
Malignant neoplasm of prepuce
187.4
Malignant neoplasm of penis, part unspecified
187.7
Malignant neoplasm of scrotum
187.9
Malignant neoplasm of male genital organ, site unspecified
190.0–190.3
Malignant neoplasm of eye
190.5–190.9
Malignant neoplasm of eye
193
Malignant neoplasm of thyroid gland
195.0
Malignant neoplasm of head, face, and neck
200.00–200.08
Reticulosarcoma
200.10–200.18
Lymphosarcoma
200.20–200.28
Burkitt’s tumor or lymphoma
200.30–200.38
Marginal zone lymphoma
200.40–200.48
Mantle cell lymphoma
200.50–200.58
Primary central nervous system lymphoma
200.60–200.68
Anaplastic large cell lymphoma
200.70–200.78
Large cell lymphoma
200.80–200.88
Other named variants of lymphosarcoma and reticulosarcoma
201.00–201.08
Hodgkin’s paragranuloma
201.10–201.18
Hodgkin’s granuloma
201.20–201.28
Hodgkin’s sarcoma
201.40–201.48
Lymphocytic-histiocytic predominance
201.50–201.58
Hodgkin’s disease, nodular sclerosis
201.60–201.68
Hodgkin’s disease, mixed cellularity
201.70–201.78
Hodgkin’s disease, lymphocytic depletion
201.90–201.98
Hodgkin’s disease, unspecified
202.00–202.08
Nodular lymphoma
202.10–202.18
Mycosis fungoides
202.20–202.28
Sezary’s disease
202.30–202.38
Malignant histiocytosis
202.40–202.48
Leukemic reticuloendotheliosis
202.50–202.58
Letterer-Siwe disease
202.60–202.68
Malignant mast cell tumors
202.70–202.78
Peripheral T cell lymphoma
202.80–202.88
Other malignant lymphomas
202.90–202.98
Other and unspecified malignant neoplasms of lymphoid and histiocytic tissue
518.7
Transfusion related acute lung injury (TRALI)
518.89
Other diseases of lung, not elsewhere classified
793.1
Nonspecific abnormal findings on radiological and other examination of lung field
793.91
Image test inconclusive due to excess body fat
793.99
Other nonspecific (abnormal) findings on radiological and other examination of body structure
V10.3
Personal history of malignant neoplasm, breast
V10.82*
Personal history of malignant melanoma of skin
Note: Use V10.82 when PET is used in restaging of malignant melanoma of skin.
V70.7*
Examination of participant in clinical trial
Note: V70.7* is used on claims for participants registered in CMS-approved clinical trial. Part A only
V71.1*
Observation for suspected malignant neoplasm, not found
Note: V71.1* should be used in reference to the metastatic evaluation of those primary neoplasms covered in the NCD (Pub. 100-04, Chapter 1, Part 4, Section 220.6).
PET imaging services performed on or after April 3, 2009, on patients with known or suspected cancer –Initial Treatment Strategy
PET imaging (CPT codes 78608, 78811, 78812, 78813, 78814, 78815 and 78816) performed on or after April 3, 2009, for determination of initial treatment strategy for suspected or biopsy-proven solid tumors must be reported with modifier PI.
Per CMS NCD, Medicare is establishing the following limited coverage for determination of initial treatment strategy forCPT/HCPCS codes A9552, 78608, 78811, 78812, 78813, 78814, 78815 and 78816:
Covered for:
Table A
140.0–140.1
Malignant neoplasm of lip
140.3–140.6
Malignant neoplasm of lip
140.8–140.9
Malignant neoplasm of lip
141.0–141.6
Malignant neoplasm of tongue
141.8–141.9
Malignant neoplasm of tongue
142.0–142.2
Malignant neoplasm of major salivary glands
142.8–142.9
Malignant neoplasm of major salivary glands
143.0–143.1
Malignant neoplasm of gum
143.8–143.9
Malignant neoplasm of gum
144.0–144.1
Malignant neoplasm of floor of mouth
144.8–144.9
Malignant neoplasm of floor of mouth
145.0–145.6
Malignant neoplasm of other and unspecified parts of mouth
145.8–145.9
Malignant neoplasm of other and unspecified parts of mouth
146.0–146.9
Malignant neoplasm of oropharynx
147.0–147.3
Malignant neoplasm of nasopharynx
147.8–147.9
Malignant neoplasm of nasopharynx
148.0–148.3
Malignant neoplasm of hypopharynx
148.8–148.9
Malignant neoplasm of hypopharynx
149.0–149.1
Malignant neoplasm of other and ill-defined sites within the lip, oral cavity, and pharynx
149.8–149.9
Malignant neoplasm of other and ill-defined sites within the lip, oral cavity, and pharynx
150.0–150.5
Malignant neoplasm of esophagus
150.8–150.9
Malignant neoplasm of esophagus
151.0–151.6
Malignant neoplasm of stomach
151.8–151.9
Malignant neoplasm of stomach
152.0–152.3
Malignant neoplasm of small intestine, including duodenum
152.8–152.9
Malignant neoplasm of small intestine, including duodenum
153.0–153.9
Malignant neoplasm of colon
154.0–154.3
Malignant neoplasm of rectum, rectosigmoid junction, and anus
154.8
Malignant neoplasm of rectum, rectosigmoid junction, and anus
155.0–155.2
Malignant neoplasm of liver and intrahepatic bile ducts
156.0–156.2
Malignant neoplasm of gallbladder and extrahepatic bile ducts
156.8–156.9
Malignant neoplasm of gallbladder and extrahepatic bile ducts
157.0–157.4
Malignant neoplasm of pancreas
157.8–157.9
Malignant neoplasm of pancreas
158.0
Malignant neoplasm of retroperitoneum
158.8–158.9
Malignant neoplasm of peritoneum
159.0–159.1
Malignant neoplasm of other and ill-defined sites within digestive tract and peritoneum
159.8–159.9
Malignant neoplasm of other and ill-defined sites within digestive tract and peritoneum
160.0–160.5
Malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
160.8–160.9
Malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
161.0–161.3
Malignant neoplasm of larynx
161.8–161.9
Malignant neoplasm of larynx
162.0
Malignant neoplasm of trachea
162.2–162.5
Malignant neoplasm of trachea, bronchus and lung
162.8–162.9
Malignant neoplasm of trachea, bronchus and lung
163.0–163.1
Malignant neoplasm of pleura
163.8–163.9
Malignant neoplasm of pleura
164.0–164.3
Malignant neoplasm of thymus, heart, and mediastinum
164.8–164.9
Malignant neoplasm of thymus, heart, and mediastinum
165.0
Malignant neoplasm of other and ill-defined sites within respiratory system and intrathoracic organs
165.8–165.9
Malignant neoplasm of other and ill-defined sites within respiratory system and intrathoracic organs
170.0–170.9
Malignant neoplasm of bone and articular cartilage
171.0
Malignant neoplasm of connective and other soft tissue
171.2–171.9
Malignant neoplasm of connective and other soft tissue
172.0–172.9***
Malignant melanoma of skin
173.0–173.9
Other malignant neoplasm of skin
174.0–174.6***
Malignant neoplasm of female breast
174.8–174.9***
Malignant neoplasm of female breast
175.0***
Malignant neoplasm of male breast, nipple and areola
175.9***
Malignant neoplasm of other and unspecified sites of male breast
176.0–176.5
Kaposi’s sarcoma
176.8–176.9
Kaposi’s sarcoma
179
Malignant neoplasm of uterus, part unspecified
180.0–180.1***
Malignant neoplasm of cervix uteri
180.8–180.9***
Malignant neoplasm of cervix uteri
181
Malignant neoplasm of placenta
182.0–182.1
Malignant neoplasm of body of uterus
182.8
Malignant neoplasm of body of uterus
183.0
Malignant neoplasm of ovary
183.2–183.5
Malignant neoplasm of fallopian tube and uterine adnexa
183.8–183.9
Malignant neoplasm of uterine adnexa
184.0–184.4
Malignant neoplasm of other and unspecified sites of female genital organs
184.8–184.9
Malignant neoplasm of other specified/unspecified sites of female genital organs
186.0
Malignant neoplasm of testis
186.9
Malignant neoplasm of testis
187.1–187.9
Malignant neoplasm of penis and other male genital organs
188.0–188.9
Malignant neoplasm of bladder
189.0–189.4
Malignant neoplasm of kidney, ureter, urethra, and paraurethral glands
189.8–189.9
Malignant neoplasm of other and unspecified urinary organs
190.0–190.9
Malignant neoplasm of eye
191.0–191.9
Malignant neoplasm of brain
192.0–192.3
Malignant neoplasm of other and unspecified parts of nervous system
192.8–192.9
Malignant neoplasm of other and unspecified parts of nervous system
193
Malignant neoplasm of thyroid gland
194.0–194.1
Malignant neoplasm adrenal gland and parathyroid gland
194.3–194.6
Malignant neoplasm of other endocrine organs and related structures
194.8–194.9
Malignant neoplasm of other and unspecified endocrine organs and related structures
195.0–195.5***
Malignant neoplasm of other and ill defined sites
195.8***
Malignant neoplasm of other and ill defined sites
196.0–196.3***
Secondary and unspecified malignant neoplasm of lymph nodes
196.5–196.6***
Secondary and unspecified malignant neoplasm of lymph nodes
196.8–196.9***
Secondary and unspecified malignant neoplasm of lymph nodes
197.0–197.8***
Secondary malignant neoplasm of respiratory and digestive systems
198.0–198.7***
Secondary malignant neoplasm of other specified sites
198.81–198.82***
Secondary malignant neoplasm of other specified sites
198.89***
Secondary malignant neoplasm of other specified sites
199.0–199.2***
Malignant neoplasm without specification of site
200.00–200.08
Reticulosarcoma
200.10–200.18
Lymphosarcoma
200.20–200.28
Burkitt’s tumor or lymphoma
200.30–200.38
Marginal zone lymphoma
200.40–200.48
Mantle cell lymphoma
200.50–200.58
Primary central nervous system lymphoma
200.60–200.68
Anaplastic large cell lymphoma
200.70–200.78
Large cell lymphoma
200.80–200.88
Other named variants of lymphosarcoma and reticulosarcoma
201.00–201.08
Hodgkin’s paragranuloma
201.10–201.18
Hodgkin’s granuloma
201.20–201.28
Hodgkin’s sarcoma
201.40–201.48
Lymphocytic-histiocytic predominance
201.50–201.58
Hodgkin’s disease, nodular sclerosis
201.60–201.68
Hodgkin’s disease, mixed cellularity
201.70–201.78
Hodgkin’s disease, lymphocytic depletion
201.90–201.98
Hodgkin’s disease, unspecified
202.00–202.08
Nodular lymphoma
202.10–202.18
Mycosis fungoides
202.20–202.28
Sezary’s disease
202.30–202.38
Malignant histiocytosis
202.40–202.48
Leukemic reticuloendotheliosis
202.50–202.58
Letterer-Siwe Disease
202.60–202.68
Malignant mast cell tumors
202.70–202.78
Peripheral T cell lymphoma
202.80–202.88
Other malignant lymphomas
202.90–202.98
Other and unspecified malignant neoplasms of lymphoid and histiocytic tissue
203.00–203.02
Multiple myeloma
203.10–203.12
Plasma cell leukemia
203.80–203.82
Other immunoproliferative neoplasms
204.00–204.02*
Acute Lymphoid leukemia
204.10–204.12*
Chronic lymphoid leukemia
204.20–204.22*
Subacute lymphoid leukemia
204.80–204.82*
Other lymphoid leukemia
204.90–204.92*
Unspecified lymphoid leukemia
205.00–205.02*
Acute Myeloid leukemia
205.10–205.12*
Chronic myeloid leukemia
205.20–205.22*
Subacute myeloid leukemia
205.30–205.32*
Myeloid sarcoma
205.80–205.82*
Other myeloid leukemia
205.90–205.92*
Unspecified myeloid leukemia
206.00–206.02*
Acute monocytic leukemia
206.10–206.12*
Chronic monocytic leukemia
206.20–206.22*
Subacute monocytic leukemia
206.80–206.82*
Other monocytic leukemia
206.90–206.92*
Unspecified monocytic leukemia
207.00–207.02*
Acute erythremia and erythroleukemia
207.10–207.12*
Chronic erythremia
207.20–207.22*
Megakaryocytic leukemia
207.80–207.82*
Other specified leukemia
208.00–208.02*
Acute leukemia of unspecified cell type
208.10–208.12*
Chronic leukemia of unspecified cell type
208.20–208.22*
Subacute leukemia of unspecified cell type
208.80–208.82*
Other leukemia of unspecified cell type
208.90–208.92*
Unspecified leukemia
209.00–209.03
Malignant carcinoid tumors of the small intestine
209.10–209.17
Malignant carcinoid tumors of the appendix, large intestine, and rectum
209.20–209.27
Malignant carcinoid tumors of other and unspecified sites
209.29
Malignant carcinoid tumors of other sites
209.30–209.36
Malignant poorly differentiated neuroendocrine tumors
235.0–235.9***
Neoplasm of uncertain behavior of digestive and respiratory system
236.0–236.7***
Neoplasm of uncertain behavior of genitourinary organs
236.90–236.91***
Neoplasm of uncertain behavior of genitourinary organs
236.99***
Neoplasm of uncertain behavior of genitourinary organs
237.0–237.6***
Neoplasm of uncertain behavior of endocrine glands and nervous system
237.9***
Neoplasm of uncertain behavior of endocrine glands and nervous system
238.0–238.3***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
238.5–238.6***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
238.8–238.9***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
793.0–793.7***
Other nonspecific (abnormal) findings on radiological and other examination of body structure
793.91***
Image test inconclusive due to excess body fat
V71.1***
Observation for suspected malignant neoplasm, not found
PET imaging services performed on or after April 3, 2009, on patients with known cancer – Subsequent Treatment Strategy
PET imaging (CPT codes 78608, 78811, 78812, 78813, 78814, 78815 and 78816) performed for determination of subsequent treatment strategy for patients with known cancer must be reported with modifier PS.
Per CMS NCD, Medicare is establishing the following limited coverage for determination of subsequent treatment strategy for CPT/HCPCS codes A9552, 78608, 78811, 78812, 78813, 78814, 78815 and 78816:
Covered for:
Table B
140.0–140.1
Malignant neoplasm of lip
140.3–140.6
Malignant neoplasm of lip
140.8–140.9
Malignant neoplasm of lip
141.0–141.6
Malignant neoplasm of tongue
141.8–141.9
Malignant neoplasm of tongue
142.0–142.2
Malignant neoplasm of major salivary glands
142.8–142.9
Malignant neoplasm of major salivary glands
143.0–143.1
Malignant neoplasm of gum
143.8–143.9
Malignant neoplasm of gum
144.0–144.1
Malignant neoplasm of floor of mouth
144.8–144.9
Malignant neoplasm of floor of mouth
145.0–145.6
Malignant neoplasm of other and unspecified parts of mouth
145.8–145.9
Malignant neoplasm of other and unspecified parts of mouth
146.0–146.9
Malignant neoplasm of oropharynx
147.0–147.3
Malignant neoplasm of nasopharynx
147.8–147.9
Malignant neoplasm of nasopharynx
148.0–148.3
Malignant neoplasm of hypopharynx
148.8–148.9
Malignant neoplasm of hypopharynx
149.0–149.1
Malignant neoplasm of other and ill-defined sites within the lip, oral cavity, and pharynx
149.8–149.9
Malignant neoplasm of other and ill-defined sites within the lip, oral cavity, and pharynx
150.0–150.5
Malignant neoplasm of esophagus
150.8–150.9
Malignant neoplasm of esophagus
151.0–151.6*
Malignant neoplasm of stomach
151.8–151.9*
Malignant neoplasm of stomach
152.0–152.3*
Malignant neoplasm of small intestine
152.8–152.9*
Malignant neoplasm of small intestine
153.0–153.9
Malignant neoplasm of colon
154.0–154.3
Malignant neoplasm of rectum, rectosigmoid, and anus
154.8
Malignant neoplasm of rectum, rectosigmoid, and anus
155.0–155.2*
Malignant neoplasm of liver and intrahepatic bile ducts
156.0–156.2*
Malignant neoplasm of gallbladder and extrahepatic bile ducts
156.8–156.9*
Malignant neoplasm of gallbladder and extrahepatic bile ducts
157.0–157.4*
Malignant neoplasm of pancreas
157.8–157.9*
Malignant neoplasm of pancreas
158.0*
Malignant neoplasm of retroperitoneum
158.8–158.9*
Malignant neoplasm of peritoneum
159.0–159.1*
Malignant neoplasm of other and ill-defined sites within digestive tract and peritoneum
159.8–159.9*
Malignant neoplasm of other and ill-defined sites within digestive tract and peritoneum
160.0–160.5
Malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
160.8–160.9
Malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
161.0–161.3
Malignant neoplasm of larynx
161.8–161.9
Malignant neoplasm of larynx
162.0**
Malignant neoplasm of trachea
162.2–162.5**
Malignant neoplasm of trachea, bronchus and lung
162.8–162.9**
Malignant neoplasm of trachea, bronchus and lung
163.0–163.1*
Malignant neoplasm of pleura
163.8–163.9*
Malignant neoplasm of pleura
164.0–164.3*
Malignant neoplasm of thymus, heart, and mediastinum
164.8–164.9*
Malignant neoplasm of thymus, heart, and mediastinum
165.0*
Malignant neoplasm of other and ill-defined sites within respiratory system and intrathoracic organs
165.8–165.9*
Malignant neoplasm of other and ill-defined sites within respiratory system and intrathoracic organs
170.0–170.1*
Malignant neoplasm of bone and articular cartilage
170.2–170.9*
Malignant neoplasm of bone and articular cartilage
171.0*
Malignant neoplasm of connective and other soft tissue
171.2–171.9*
Malignant neoplasm of connective and other soft tissue
172.0–172.9
Malignant melanoma of skin
173.0–173.4*
Other malignant neoplasm of skin
173.5–173.9*
Other malignant neoplasm of skin
174.0–174.6
Malignant neoplasm of female breast
174.8–174.9
Malignant neoplasm of female breast
175.0
Malignant neoplasm of male breast, nipple and areola
175.9
Malignant neoplasm of other and unspecified sites of male breast
176.0–176.1*
Kaposi’s sarcoma
176.2*
Kaposi’s sarcoma, palate
176.3–176.5*
Kaposi’s sarcoma
176.8–176.9*
Kaposi’s sarcoma
179*
Malignant neoplasm of uterus, part unspecified
180.0–180.1
Malignant neoplasm of cervix uteri
180.8–180.9
Malignant neoplasm of cervix uteri
181*
Malignant neoplasm of placenta
182.0–182.1*
Malignant neoplasm of body of uterus
182.8*
Malignant neoplasm of body of uterus
183.0
Malignant neoplasm of ovary
183.2–183.5*
Malignant neoplasm of fallopian tube and uterine adnexa
183.8–183.9*
Malignant neoplasm of uterine adnexa
184.0–184.4*
Malignant neoplasm of other and unspecified sites of female genital organs
184.8–184.9*
Malignant neoplasm of other specified/unspecified sites of female genital organs
185*
Malignant neoplasm of prostate
186.0*
Malignant neoplasm of testis
186.9*
Malignant neoplasm of testis
187.1–187.9*
Malignant neoplasm of penis and other male genital organs
188.0–188.9*
Malignant neoplasm of bladder
189.0–189.4*
Malignant neoplasm of kidney, ureter, urethra, and paraurethral glands
189.8–189.9*
Malignant neoplasm of other and unspecified urinary organs
190.0–190.9*
Malignant neoplasm of eye
191.0–191.9*
Malignant neoplasm of brain
192.0–192.3*
Malignant neoplasm of other and unspecified parts of nervous system
192.8–192.9*
Malignant neoplasm of other and unspecified parts of nervous system
193***
Malignant neoplasm of thyroid gland
194.0*
Malignant neoplasm of adrenal gland
194.1*
Malignant neoplasm of parathyroid gland
194.3–194.4*
Malignant neoplasm of other endocrine organs and related structures
194.5
Malignant neoplasm of other endocrine organs and related structures
194.6*
Malignant neoplasm of other endocrine organs and related structures
194.8–194.9*
Malignant neoplasm of other endocrine organs and related structures
195.0
Malignant neoplasm of other and ill defined sites
195.1–195.8***
Malignant neoplasm of other and ill defined sites
196.0–196.3***
Secondary and unspecified malignant neoplasm of lymph nodes
196.5–196.6***
Secondary and unspecified malignant neoplasm of lymph nodes
196.8–196.9***
Secondary and unspecified malignant neoplasm of lymph nodes
197.0–197.8***
Secondary malignant neoplasm of respiratory and digestive systems
198.0–198.7***
Secondary malignant neoplasm of other specified sites
198.81–198.82***
Secondary malignant neoplasm of other specified sites
198.89***
Secondary malignant neoplasm of other specified sites
199.0–199.2***
Malignant neoplasm without specification of site
200.00–200.08
Reticulosarcoma
200.10–200.18
Lymphosarcoma
200.20–200.28
Burkitt’s tumor or lymphoma
200.30–200.38
Marginal zone lymphoma
200.40–200.48
Mantle cell lymphoma
200.50–200.58
Primary central nervous system lymphoma
200.60–200.68
Anaplastic large cell lymphoma
200.70–200.78
Large cell lymphoma
200.80–200.88
Other named variants of lymphosarcoma and reticulosarcoma
201.00–201.08
Hodgkin’s paragranuloma
201.10–201.18
Hodgkin’s granuloma
201.20–201.28
Hodgkin’s sarcoma
201.40–201.48
Lymphocytic-histiocytic predominance
201.50–201.58
Hodgkin’s disease, nodular sclerosis
201.60–201.68
Hodgkin’s disease, mixed cellularity
201.70–201.78
Hodgkin’s disease, lymphocytic depletion
201.90–201.98
Hodgkin’s disease, unspecified
202.00–202.08
Nodular lymphoma
202.10–202.18
Mycosis fungoides
202.20–202.28
Sezary’s disease
202.30–202.38
Malignant histiocytosis
202.40–202.48
Leukemic reticuloendotheliosis
202.50–202.58
Letterer-Siwe Disease
202.60–202.68
Malignant mast cell tumors
202.70–202.78
Peripheral T cell lymphoma
202.80–202.88
Other malignant lymphomas
202.90–202.98
Other and unspecified malignant neoplasms of lymphoid and histiocytic tissue
203.00–203.02
Multiple myeloma
203.10–203.12
Plasma cell leukemia
203.80–203.82
Other immunoproliferative neoplasms
204.00–204.02*
Acute Lymphoid leukemia
204.10–204.12*
Chronic lymphoid leukemia
204.20–204.22*
Subacute lymphoid leukemia
204.80–204.82*
Other lymphoid leukemia
204.90–204.92*
Unspecified lymphoid leukemia
205.00–205.02*
Acute Myeloid leukemia
205.10–205.12*
Chronic myeloid leukemia
205.20–205.22*
Subacute myeloid leukemia
205.30–205.32*
Myeloid sarcoma
205.80–205.82*
Other myeloid leukemia
205.90–205.92*
Unspecified myeloid leukemia
206.00–206.02*
Acute Monocytic leukemia
206.10–206.12*
Chronic monocytic leukemia
206.20–206.22*
Subacute monocytic leukemia
206.80–206.82*
Other monocytic leukemia
206.90–206.92*
Unspecified monocytic leukemia
207.00–207.02*
Acute erythremia and erythroleukemia
207.10–207.12*
Chronic erythremia
207.20–207.22*
Megakaryocytic leukemia
207.80–207.82*
Other specified leukemia
208.00–208.02*
Acute leukemia of unspecified cell type
208.10–208.12*
Chronic leukemia of unspecified cell type
208.20–208.22*
Subacute leukemia of unspecified cell type
208.80–208.82*
Other leukemia of unspecified cell type
208.90–208.92*
Unspecified leukemia
209.00–209.03*
Malignant carcinoid tumors of the small intestine
209.10–209.17*
Malignant carcinoid tumors of the appendix, large intestine, and rectum
209.20–209.27*
Malignant carcinoid tumors of other and unspecified sites
209.29*
Malignant carcinoid tumors of other sites
209.30–209.32*
Malignant poorly differentiated neuroendocrine tumors
209.33–209.36*
Malignant poorly differentiated neuroendocrine tumors
235.0–235.9***
Neoplasm of uncertain behavior of digestive and respiratory system
236.0–236.7***
Neoplasm of uncertain behavior of genitourinary organs
236.90–236.91***
Neoplasm of uncertain behavior of genitourinary organs
236.99***
Neoplasm of uncertain behavior of genitourinary organs
237.0–237.6***
Neoplasm of uncertain behavior of endocrine glands and nervous system
237.9***
Neoplasm of uncertain behavior of endocrine glands and nervous system
238.0–238.2***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
238.3***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
238.5–238.6***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
238.8–238.9***
Neoplasm of uncertain behavior of other and unspecified sites and tissues
V58.0***
Encounter for radiotherapy
V58.11***
Encounter for antineoplastic chemotherapy
V58.42***
Aftercare for neoplasm following surgery
V67.00***
Following surgery, unspecified
V67.1–V67.2***
Following radiotherapy and chemotherapy
*These diagnoses are covered only when provided in an approved clinical research study. Report these codes with the Q0 modifier to signify services provided in such a study.
**Subsequent treatment strategy PET imaging is covered only for non-small-cell tumors. Other lung cancers reported with these codes are covered only in an approved clinical research study and must be reported with the Q0 modifier.
*** For all diagnoses marked with three asterisks, providers must follow provisions of the NCD and only report for payment appropriate tumors and cancers as specified (i.e., report for payment those tumors covered under CED when performed according to NCD provisions and not reporting non-covered tumors). When reporting secondary tumors, follow NCD for coverage of PET imaging for primary tumor site when origin is known.
PET imaging services with NaF-18, performed on or after February 26, 2010, on patients with known or suspected metastatic cancer to bone – Initial Treatment Strategy (PI) and for patients with known metastatic cancer to bone – Subsequent Treatment Strategy (PS)
Per the CMS NCD, CPT/HCPCS codes A9580, 78811, 78812, 78813, 78814, 78815 and 78816 are covered for all diagnoses listed in the PI and PS covered diagnosis tables A and B above. Providers must follow provisions of the NCD and only report for payment appropriate tumors and cancers as specified by the NCD. These services are covered only when provided in an approved clinical research study. Report these codes with the Q0 modifier to signify services provided in such a study.
When reporting NaF PET imaging for metastatic bone cancer, modifiers PI or PS must also be appended to indicate initial or subsequent treatment strategy, respectively. Report modifier KX with all other required modifiers on claims for the professional component of PET imaging services (modifier 26 services) to indicate covered NaF-18 services for metastatic cancer to bone.
Note: Providers should continue to submit ICD-9-CM diagnosis codes without decimals on their claim forms and electronic claims.